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The decrease in the rate of bone resorption indicated by these markers was evident as early as one month and at three to six months reached a plateau that was maintained for the entire duration of treatment with alendronate. Seems like doctors are washing their hands of this medication and just continue to prescribe it. This pain at times is almost unbearable. I am on Gabapentin 300 mg. twice a day and it seems to help sometimes. On occasion, when I can't stand it anymore, I take 800 mg. of Ibuprofen and that is happening more and more often. It literally has ruined my life as I once knew it. I can no longer do the type of work I used to. What really scares me is that this junk stays in your body for TEN years. Let me know how you are doing and what you think about the FDA report. Maybe you want to print it out and take it to your doctor with you. selegiline

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Your doctor or dentist may tell you to stop taking alendronate before your surgery. Follow all instructions about stopping or starting this medication. Instruct patients to read the Medication Guide before starting therapy with Alendronate sodium and to reread it each time the prescription is renewed. If you miss a dose of Alendronate sodium tablets, do not take it later in the day. Take your missed dose on the next morning after you remember and then return to your normal schedule. Do not take 2 doses on the same day.

N-telopeptides of type I collagen

Three-Year Study of FIT. Iron Salts: May decrease the serum concentration of Bisphosphonate Derivatives. It is not known whether alendronate passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. If you are concerned about the bone-thinning disease osteoporosis, you may have heard about treatment with strontium. The two treatment groups were also similar with regard to BMD increases at other skeletal sites. The results of the intention-to-treat analysis were consistent with the primary analysis of completers.

What conditions does alendronate treat

Are allergic to alendronate or any of its ingredients. A list of ingredients is at the end of this leaflet. Abdominal pain, acid regurgitation, constipation, diarrhea, dyspepsia, musculoskeletal pain, nausea. How should I store the TYMLOS pen? Do not chew or suck on a tablet of Alendronate sodium.



Alendronate consumer information

Do not stop taking any medications without consulting your healthcare provider. Read the Medication Guide provided by your pharmacist before you start taking alendronate and each time you get a refill. Follow the instructions very closely to make sure your body absorbs as much drug as possible and to reduce the risk of injury to your esophagus. If you have any questions, ask your doctor or pharmacist. Do not lie down. Increased blood calcium hypercalcemia. Fosamax and glucocorticoid treatment. American Association of Clinical Endocrinologists. AACE clinical practice guidelines for the prevention and treatment of postmenopausal osteoporosis; 1996. See “What is the most important information I should know about Alendronate sodium tablets? Mbekeani JN, Slamovits TL, Schwartz BH, Sauer HL "Ocular inflammation associated with alendronate therapy. Excessive osteoclastic bone resorption is followed by osteoblastic new bone formation, leading to the replacement of the normal bone architecture by disorganized, enlarged, and weakened bone structure.



List of alendronate side effects

Seeman E. Osteoporosis: trials and tribulations. Am J Med. There is no evidence that Alendronate is metabolized in animals or humans. Talk to your doctor or about lifestyle changes that might benefit you. See FDA-approved patient labeling Medication Guide. Counting to 10 will allow the full dose of TYMLOS to be given. In the pooled analysis, patients who received alendronate had a loss in stature that was statistically significantly less than was observed in those who received placebo -3. If patients miss a dose of once weekly Alendronate sodium, instruct patients to take one dose on the morning after they remember. They should not take two doses on the same day but should return to taking one dose once a week, as originally scheduled on their chosen day. Your doctor may prescribe calcium and vitamin D to help prevent low calcium levels in your blood, while you take Alendronate sodium tablets. Ravn P, Bidstrup M, Wasnich RD, et al. "Alendronate and estrogen-progestin in the long-term prevention of bone loss: four-year results from the early postmenopausal intervention cohort study: a randomized, controlled trial. triamcinolone



Alendronate drug interactions

De Groen PC, Lubbe DF, Hirsch LJ et al. Esophagitis associated with the use of alendronate. N Engl J Med. This combination is used to prevent or treat low levels in people who not get enough from their diets. Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice. Cummings SR, Schwartz AV, Black DM. Alendronate and atrial fibrillation. N Engl J Med. Whatever treatment you use, keep in mind that researchers are working all the time to find new ways to treat Gaucher's in clinical trials. These studies test new drugs to see if they're safe and if they work. They are often a way for people to try new medicine that isn't available to everyone. Talk to your doctor to see if one of these trials might be a good fit for you. Black DM, Cummings SR, Karpf DB et al. for the Fracture Intervention Trial Research Group. Randomized trial of effect of alendronate on risk of fracture in women with existing vertebral fractures. Lancet. This drug should not be taken with mineral water, coffee, tea, soda, or juice. Hepatic Impairment: As there is evidence that alendronate is not metabolized or excreted in the bile, no studies were conducted in patients with hepatic impairment. No dosage adjustment is necessary. No overall differences in efficacy or safety were observed between these patients and younger patients, but greater sensitivity of some older individuals cannot be ruled out. Adachi JD, Bensen WG, Brown J et al. Intermittent etidronate therapy to prevent corticosteroid-induced osteoporosis. N Engl J Med. It is not known whether alendronate is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when alendronate is administered to nursing women. Merck. Fosamax alendronate sodium tablets and oral solution prescribing information. Whitehouse Station, NJ; 2011 Jan. Patient may experience headache, constipation, or diarrhea. Have patient report immediately to prescriber signs of low calcium muscle cramps or spasms, numbness and tingling, or seizures; black, tarry, or bloody stools; angina; coughing up blood; severe abdominal pain; heartburn; difficulty swallowing; pain when swallowing; pharyngitis; severe nausea; severe vomiting; vomiting blood; severe bone pain; severe joint pain; severe muscle pain; groin, hip, or thigh pain; mouth sores; or jaw pain, or edema HCAHPS. In double-blind, multicenter, controlled studies, asymptomatic, mild, and transient decreases in serum calcium and phosphate were observed in approximately 18% and 10%, respectively, of patients taking Fosamax versus approximately 12% and 3% of those taking placebo. Not known whether alendronate is distributed into milk. 1 112 Caution if used in nursing women. American College of Rheumatology Task Force on Osteoporosis Guidelines. Recommendations for the prevention and treatment of glucocorticoid-induced osteoporosis. Arthritis Rheumatism. astux.info estrace



What happens if I miss a dose Fosamax?

Fosamax 70 mg oral solution and Fosamax 70 mg tablet are equally bioavailable. Alendronate is in the group of medicines called bisphosphonates bis FOS fo nayts. It alters the cycle of bone formation and breakdown in the body. Alendronate slows bone loss while increasing bone mass, which may prevent bone fractures. The onset of pain ranged from a single day to several months. Consider discontinuing therapy in patients who experience severe symptoms; symptoms usually resolve upon discontinuation. Some patients experienced recurrence when rechallenged with same drug or another bisphosphonate; avoid use in patients with a history of these symptoms in association with bisphosphonate therapy. Eli Lilly and Company. Evista raloxifene hydrochloride tablets prescribing information. Skelid and zoledronic acid Reclast, Zometa. 2008 Nov 12. Available from FDA website. best price generic quetiapine



See Figure 3 for lumbar spine results

N-telopeptides of type I collagen. Body as a Whole: hypersensitivity reactions including urticaria and angioedema. Transient symptoms of myalgia, malaise, asthenia and fever have been reported with alendronate, typically in association with initiation of treatment. Symptomatic hypocalcemia has occurred, generally in association with predisposing conditions. Peripheral edema. Prevention of bone loss was demonstrated in two double-blind, placebo-controlled studies of postmenopausal women 40-60 years of age. Take Fosamax with a full glass 6 to 8 ounces of water. Use only plain water not mineral water when taking the tablet. Store at room temperature away from light and moisture. See packaging for the exact temperature range. Are allergic to Fosamax or any of its ingredients. A list of ingredients is at the end of this leaflet. FOSAMAX is not indicated for use in pediatric patients. It is important that you take Alendronate sodium tablets exactly as prescribed to help lower your chance of getting esophagus problems. See the section “How should I take Alendronate sodium tablets? Importance of advising patients of other important precautionary information. 1 See Cautions. Bioavailability was negligible whether Alendronate was administered with or up to two hours after a standardized breakfast. Concomitant administration of Alendronate with coffee or orange juice reduced bioavailability by approximately 60%. The efficacy of Fosamax in men with hypogonadal or idiopathic osteoporosis was demonstrated in two clinical studies. Alendronate 40 mg once daily for 6 months. Avoid taking any other medicines including vitamins, calcium, or antacids for at least 30 minutes after taking alendronate. Some medicines can make it harder for your body to absorb alendronate. Panel members who voted to keep calcitonin salmon on the market feel the cancer risk is low and that the drug could benefit specific patients. If a once-weekly dose of Alendronate sodium tablets is missed, instruct patients to take one dose on the morning after they remember. They should not take two doses on the same day but should return to taking one dose once a week, as originally scheduled on their chosen day. Resume the next dose on its regular schedule. vivitrol



Before taking alendronate

Store at room temperature away from moisture and heat. What happens if I miss a dose? Health Care Financing Administration. Medicare program; medicare coverage of and payment for bone mass measurements. 42 CFR Part 410. Interim rule. Fed Regist. Bisphosphonates are incorporated into the bone matrix, from which they are gradually released over a period of years. The amount of bisphosphonate incorporated into adult bone, and hence, the amount available for release back into the systemic circulation, is directly related to the dose and duration of bisphosphonate use. There are no data on fetal risk in humans. However, there is a theoretical risk of fetal harm, predominantly skeletal, if a woman becomes pregnant after completing a course of bisphosphonate therapy. The impact of variables such as time between cessation of bisphosphonate therapy to conception, the particular bisphosphonate used, and the route of administration intravenous versus oral on the risk has not been studied. Often occurs with minimal or no trauma, and may be bilateral. 89 90 91 93 Causality not established; atypical fractures also occur in osteoporotic patients not receiving bisphosphonates. 91 92 93 94 Risk may be increased with concomitant use of glucocorticoid, estrogen, and proton-pump inhibitor therapy. Body as a Whole: hypersensitivity reactions including urticaria and angioedema. Transient symptoms of myalgia, malaise, asthenia and fever have been reported with Alendronate sodium, typically in association with initiation of treatment. Symptomatic hypocalcemia has occurred, generally in association with predisposing conditions. Peripheral edema. Further hydroxylation occurs prior to elimination.



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Read the Medication Guide that comes with alendronate before you start taking it and each time you get a refill. There may be new information. This Medication Guide does not take the place of talking with your doctor about your medical condition or treatment. Talk to your doctor if you have any questions about alendronate. FOSAMAX may lower the calcium levels in your blood. Calcium or iron supplements, vitamins, antacids, coffee, tea, soda, mineral water, calcium-enriched juices, and food can decrease the absorption of alendronate. Do not take these for at least 30 minutes preferably 1 to 2 hours after taking alendronate. Keep Alendronate sodium tablets in a tightly closed container. If your doctor has recommended that you follow a special diet, it is very important to follow the diet to get the most benefit from this medication and to prevent serious side effects. Study 3, the Three-Year Study of the Fracture Intervention Trial FIT a study which enrolled 2027 postmenopausal patients with at least one baseline vertebral fracture; and Study 4, the Four-Year Study of FIT: a study which enrolled 4432 postmenopausal patients with low bone mass but without a baseline vertebral fracture. FDA pregnancy category C. It is not known whether alendronate will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. Solomon DH, Patrick A, Brookhart MA. More on reports of esophageal cancer with oral bisphosphonate use. N Engl J Med. It may harm them. Nervous System: dizziness and vertigo. Some people who take Alendronate sodium tablets may develop problems in the esophagus the tube that connects the mouth and the stomach. These problems include irritation, inflammation, or ulcers of the esophagus which may sometimes bleed. The mean steady-state volume of distribution, exclusive of bone, is at least 28 L in humans. If you take too much alendronate, call your doctor. Do not try to vomit. Do not lie down. Keep Alendronate sodium tablets and all medicines out of the reach of children. Alendronate 10 mg once daily or 70 mg once weekly in men and postmenopausal women. order now aciphex online uk



What should i avoid while taking alendronate

Prevention of bone loss was demonstrated in two double-blind, placebo-controlled studies of postmenopausal women 40 to 60 years of age. Riggs BL. Osteoporosis. In: Wyngaarden JB, Smith LH Jr, Bennett JC, eds. Cecil textbook of medicine. Some of the side effects that can occur with alendronate may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. Abrahamsen B, Eiken P, Eastell R. More on reports of esophageal cancer with oral bisphosphonate use. N Engl J Med. Do not lie down or recline for at least 30 minutes after taking alendronate. If you miss a dose of alendronate, do not take it later in the day. Take your missed dose on the next morning after you remember and then return to your normal schedule. Do not take 2 doses on the same day. Urinary excretion is the sole means of elimination of alendronate. These increases in BMD were similar to those seen at one year in the 10 mg once-daily study. Safety labeling change and REMS notification. Silver Spring, MD; 2010 Oct 13. From FDA website. The safety of Fosamax 70 mg once weekly for the treatment of postmenopausal osteoporosis was assessed in a one-year, double-blind, multicenter study comparing Fosamax 70 mg once weekly and Fosamax 10 mg daily. The overall safety and tolerability profiles of once weekly Fosamax 70 mg and Fosamax 10 mg daily were similar. C. 112 Keep tablets in sealed blisters until immediately before use. 112 Protect from moisture and light. For at least the first 30 minutes after taking an alendronate tablet, do not lie down or recline; do not eat or drink anything other than plain water; and do not take any other medicines including vitamins, calcium, or antacids. There may be new information. This Medication Guide does not take the place of talking with your doctor about your medical condition or treatment. Talk to your doctor if you have any questions about Fosamax. As there is evidence that alendronate is not metabolized or excreted in the bile, no studies were conducted in patients with hepatic impairment. Any patient with a history of bisphosphonate exposure who presents with thigh or groin pain should be suspected of having an atypical fracture and should be evaluated to rule out an incomplete femur fracture. Patients presenting with an atypical fracture should also be assessed for symptoms and signs of fracture in the contralateral limb. norfloxacin rx medstore



Does alendronate interact with other medications

Although data are conflicting, possible increased risk of atrial fibrillation with use of bisphosphonates. 106 107 108 FDA analysis of data from long-term 6 months to 3 years controlled trials identified a higher rate of atrial fibrillation in patients receiving bisphosphonates alendronate, ibandronate, risedronate, or zoledronic acid versus placebo; however, only a few events reported in each study. 108 FDA is continuing to monitor this safety concern. Women who smoke tend to go through earlier, triggering earlier bone loss. In addition, smokers may absorb less calcium from their diets. Alcohol can also negatively affect bone health. Those who drink heavily are more prone to bone loss and fracture, both because of poor and an increased risk of falling. Alendronate sodium was effective regardless of dose or duration of glucocorticoid use. In addition, Alendronate sodium was similarly effective regardless of age less than 65 vs. greater than or equal to 65 years race Caucasian vs. other races gender, underlying disease, baseline BMD, baseline bone turnover, and use with a variety of common medications. For patent information: www. What other drugs will affect alendronate Fosamax? Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. NDC 0093-5141-56 and 100 NDC 0093-5141-01. carafate pharmacy us



FOSAMAX PLUS D can harm your unborn baby

Typically, these symptoms come and go. When symptoms are present in a person with the disease, it is known as a flare. When symptoms are not present, the disease is said to be in remission. Fleisch H. The use of bisphosphonates in osteoporosis. Br J Clin Pract. Your doctor may prescribe calcium and vitamin D to help prevent low calcium levels in your blood, while you take alendronate. As there is evidence that Alendronate is not metabolized or excreted in the bile, no studies were conducted in patients with hepatic impairment. Metabolism: There is no evidence that alendronate is metabolized in animals or humans. Take this by with food. Fosamax and 3 of 30 10% patients treated with placebo. Caution is advised if you are pregnant or planning to become pregnant in the future. Alendronate may stay in your body for many years. Its effects on an unborn baby are unknown. Discuss the risks and benefits with your doctor before starting treatment with alendronate. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Stomach pain, constipation, diarrhea, gas, or nausea may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. Levy RM, Keller M et al. Risedronate therapy prevents corticosteroid-induced bone loss: a twelve-month, multicenter, randomized, double-blind, placebo-controlled, parallel-group study. Arthritis Rheum. Before you lie down. You may sit, stand or walk, and do normal activities like reading. Lowe CE, Depew WT, Vanner SJ, Paterson WG, Meddings JB "Upper gastrointestinal toxicity of alendronate. Patients at increased risk of aspiration should not receive alendronate oral solution. lasix



TYMLOS pen until you hear a click

Take1 dose of alendronate sodium oral solution every week on your chosen day after you get up for the day and before taking your first food, drink or other medicine. Drink at least 2 ounces of plain water after you drink alendronate sodium oral solution. FOSAMAX and placebo groups in reduction of bone pain. Bone HG, Greenspan SL, McKeever C, Bell N, Davidson M, Downs RW, Emkey R, Meunier PJ, Miller SS, Mulloy AL, Recker RR, We "Alendronate and estrogen effects in postmenopausal women with low bone mineral density. If you take alendronate once a week: If you forget to take alendronate on your scheduled day, take it first thing in the morning on the day after you remember the missed dose. Then return to your regular weekly schedule on your chosen dose day. Do not take two 2 tablets in one day. What happens if I overdose? Ringe JD "The interpretation of preclinical data in predicting bisphosphonate response in the treatment of osteoporosis. Gamble Pharmaceuticals. Actonel risedronate sodium tablets prescribing information. Cincinnati, OH; 2008 Apr. Treatment with Fosamax did not reduce the risk of fracture. Sixteen percent of the Fosamax patients who sustained a radiologically-confirmed fracture by Month 12 of the study had delayed fracture healing callus remodeling or fracture non-union when assessed radiographically at Month 24 compared with 9% of the placebo-treated patients. In Fosamax-treated patients, bone histomorphometry data obtained at Month 24 demonstrated decreased bone turnover and delayed mineralization time; however, there were no mineralization defects. There were no statistically significant differences between the Fosamax and placebo groups in reduction of bone pain. The oral bioavailability in children was similar to that observed in adults. WebMD User Reviews should not be considered as medical advice and are not a substitute for professional medical advice, diagnosis, or treatment. Never delay or disregard seeking professional medical advice from your physician or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences may be a helpful health information resource but they are never a substitute for professional medical advice from a qualified healthcare provider. Fosamax for either two or three years. Rash and have occurred. To be sure this medication is helping your condition, your bone mineral density will need to be tested on a regular basis. You may not need to take alendronate for longer than 3 to 5 years if you take it for osteoporosis. Visit your doctor regularly. Rosen CJ, Kessenich CR. Comparative clinical pharmacology and therapeutic use of bisphosphonates in metabolic bone diseases. Drugs. The safety of Alendronate, the free acid 70 mg once weekly for the treatment of postmenopausal osteoporosis was assessed in a one-year, double-blind, multicenter study comparing Alendronate, the free acid 70 mg once weekly and Alendronate, the free acid 10 mg daily. The overall safety and tolerability profiles of once weekly Alendronate, the free acid 70 mg and Alendronate, the free acid 10 mg daily were similar. Take Alendronate sodium tablets, after you get up for the day and before taking your first food, drink, or other medicine. Degroen PC, Lubbe DF, Hirsch LJ, Daifotis A, Stephenson W, Freedholm D, Pryortillotson S, Seleznick MJ, Pinkas H, Wang KK "Esophagitis associated with the use of alendronate.



Alendronate dosage

NSAIDs nonsteroidal anti-inflammatory drugs--ibuprofen Advil, Motrin naproxen Aleve celecoxib, diclofenac, indomethacin, meloxicam, and others. Drugs called bisphosphonates can help rebuild your weakened bones. They include alendronate Fosamax and pamidronate Aredia. You or your child can take them. Rimmer DE, Rawls DE "Improper alendronate administration and a case of pill esophagitis. Keep all regular medical and laboratory appointments. Included as part of the PRECAUTIONS section. The recommended dosage is one 5 mg tablet once daily, except for postmenopausal women not receiving estrogen, for whom the recommended dosage is one 10 mg tablet once daily. Adami S, Passeri M, Ortolani S et al. Effects of oral alendronate and intranasal salmon calcitonin on bone mass and biochemical markers of bone turnover in postmenopausal women with osteoporosis. Bone. Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Certain medicines may affect how Fosamax works. famciclovir australia cheapest



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How to use alendronate


Highlights for alendronate

Hypocalcemia: Hypocalcemia has been reported with the use of bisphosphonates. Prior to therapy initiation, hypocalcemia must be corrected; ensure adequate calcium and vitamin D intake. Osteoporosis in Postmenopausal Women: Osteoporosis is characterized by low bone mass that leads to an increased risk of fracture. The diagnosis can be confirmed by the finding of low bone mass, evidence of fracture on x-ray, a history of osteoporotic fracture, or height loss or kyphosis, indicative of vertebral spinal fracture. Osteoporosis occurs in both males and females but is most common among women following the menopause, when bone turnover increases and the rate of bone resorption exceeds that of bone formation. These changes result in progressive bone loss and lead to osteoporosis in a significant proportion of women over age 50. Fractures, usually of the spine, hip, and wrist, are the common consequences. From age 50 to age 90, the risk of hip fracture in white women increases 50-fold and the risk of vertebral fracture 15 to 30-fold. It is estimated that approximately 40% of 50-year-old women will sustain one or more osteoporosis-related fractures of the spine, hip, or wrist during their remaining lifetimes. Hip fractures, in particular, are associated with substantial morbidity, disability, and mortality.

What other drugs will affect alendronate

Cameron RB "Esophagitis dissecans superficialis and alendronate: case report. Alendronate, approximately 50% of the radioactivity was excreted in the urine within 72 hours and little or no radioactivity was recovered in the feces. Alendronate sodium may be administered to patients taking non-steroidal anti-inflammatory drugs NSAIDs.

Use of alendronate

TYMLOS increased serum concentrations. The recommended treatment regimen is 40 mg once a day for six months. In clinical studies, the incidence of upper gastrointestinal adverse events was increased in patients receiving concomitant therapy with daily doses of Fosamax greater than 10 mg and aspirin-containing products. The oral solution should be followed by at least 2 ounces of water to facilitate gastric emptying. Many people using this medication not have serious side effects.

Side effects of alendronate

Bisphosphonates may cause local irritation of the upper gastrointestinal mucosa. Esophagitis and esophageal ulcers and erosions, occasionally with bleeding, as well as gastric and duodenal ulcers, have been reported, primarily with alendronate. Because of their structural similarities, therapy with all bisphosphonates should be administered cautiously in patients with active upper gastrointestinal disorders. Lymes Disease or was getting Rheumatoid Arthritis! This may interfere with certain laboratory tests including possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.

At six months the suppression in alkaline phosphatase in patients treated with Fosamax was significantly greater than that achieved with etidronate and contrasted with the complete lack of response in placebo-treated patients. Response defined as either normalization of serum alkaline phosphatase or decrease from baseline greater than or equal to 60% occurred in approximately 85% of patients treated with Fosamax in the combined studies vs. 30% in the etidronate group and 0% in the placebo group. Fosamax was similarly effective regardless of age, gender, race, prior use of other bisphosphonates, or baseline alkaline phosphatase within the range studied at least twice the upper limit of normal. decadron purchase shop australia

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